Warning Signs a Loved One May Have an Substance Use Disorder
October 21, 2021
Ketamine and Mental Health
November 9, 2021
Show all

Can Prozac Be Misused?

Woman's hand pours the medicine pills out of the bottle

Prozac (generic name fluoxetine) is one of the most prescribed psychiatric medications in the United States. In 2019, it was prescribed 27,110,302 times to 5,143,421 patients, making it was the 20th most prescribed drug and the second most-prescribed serotonin reuptake inhibitor (SSRI) after sertraline (trade name Zoloft).1

Though some people do have adverse reactions to it, fluoxetine is overwhelmingly considered safe and non-habit-forming by American medical professionals, which is why it is so widely prescribed. However, with so many people having access to the drug, it’s almost impossible to prevent improper or unauthorized use.2

Any instance a substance is used in a way that isn’t medically prescribed is considered to be “misuse” and the misuse of fluoxetine and other antidepressant medications, while rare, is a well-attested phenomenon.2,3,4

Why Do People Misuse Prozac?

Aside from their approved use as antidepressants, Prozac and other SSRI-class drugs are widely prescribed for a wide variety of off-label purposes. They are commonly used off-label for treating anxiety disorders, obsessive-compulsive disorder, and other mental health issues associated with compulsive behavior or elevated risks of substance misuse.2,3,4

When prescribed in these scenarios, patients may take the drug in larger doses than recommended and may be more likely to continue taking them when not needed. They may also be more likely to combine fluoxetine with alcohol, which can cause a synergistic depressant effect in some individuals. Additionally, some individuals who are prone to trying any substance in an effort to get a “high” may use fluoxetine or combine it with other substances.2,3,4

One specific way that fluoxetine is sometimes misused is as a way to ease withdrawals from other substances like alcohol, cocaine, or opioids. While there have been some studies exploring the use of fluoxetine and other SSRIs for this purpose, this type of use is still not FDA-approved.2,5,6

Can You Get High On Prozac?

While extremely rare, a few individuals report feeling euphoria from Prozac. This isn’t a typical effect for most people who use the medication as indicated. Most people are likely to feel a mood “leveling” effect where they could still have more or less the same emotions that they would often feel, though not as strongly as they might without the medication. Feelings of euphoria from fluoxetine have also been attributed to a placebo effect.3,4

Effects of Fluoxetine Misuse

Using fluoxetine in a way other than indicated can bring a host of different effects. Some effects may include:2

  • Aggression
  • Tooth grinding
  • Anxiety
  • Emotional numbness
  • Suicidal ideation
  • Euphoria
  • Feelings of doom
  • Panic attacks
  • Worsened depression
  • Mania
  • Impulsive behavior
  • Excessive excitement
  • Sexual dysfunction
  • Sleep disorders

Some of these effects may still occur even at prescribed dosages. As with some other SSRI drugs, these effects may also subside within a few weeks or months of regular prescribed use.2

If you were prescribed fluoxetine or other SSRIs for a psychiatric disorder and you experience these effects, get in touch with your psychiatrist immediately. Do not stop using your medication as indicated until you have received specific instructions from your doctor.

How Common are Fluoxetine Use Disorders?

By most accounts, cases of fluoxetine misuse that lead to serious harm are incredibly rare, and “fluoxetine use disorder” is not something that is known to happen and is not discussed in the latest version of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5). Cases of regular fluoxetine misuse are usually tied to some other mental health condition.2,3,7

Find Help for Antidepressant Misuse in New England

While safe, effective, and highly beneficial for millions of people with chronic depression, fluoxetine and other SSRI class drugs do have the potential to be misused, particularly when they are taken off-label or used for a purpose other than generally recommended. Misusing antidepressants can also be a sign of some other underlying mental health issue, particularly if the individual also misuses alcohol and other drugs.2

If you’re in the New England area, help for possible drug use disorders is just a phone call away. Boston Drug Treatment Centers gives you access to some of the country’s best programs for drug and alcohol rehabilitation within the Greater Boston area. Call (857) 577-8193 to discuss your options.



  1. S. Agency for Healthcare Research and Quality & (2020). Medical Expenditure and Panel Survey 2019.


  1. Evans, E. A., & Sullivan, M. A. (2014). Abuse and misuse of antidepressants. Substance abuse and rehabilitation5, 107–120. https://doi.org/10.2147/SAR.S37917


  1. Tinsley, J. A., Olsen, M. W., Laroche, R. R., & Palmen, M. A. (1994, February). Fluoxetine abuse. In Mayo Clinic Proceedings(Vol. 69, No. 2, pp. 166-168). Elsevier.


  1. Pagliaro, L. A., & Pagliaro, A. M. (1993). Fluoxetine abuse by an intravenous drug userThe American journal of psychiatry.


  1. Bertschy, G., Eap, C. B., Powell, K., & Baumann, P. (1996). Fluoxetine addition to methadone in addicts: pharmacokinetic aspectsTherapeutic Drug Monitoring18(5), 570-572.


  1. Krupitsky, E. M., Zvartau, E. E., Masalov, D. V., Tsoy, M. V., Burakov, A. M., Egorova, V. Y., … & Woody, G. E. (2006). Naltrexone with or without fluoxetine for preventing relapse to heroin addiction in St. Petersburg, RussiaJournal of substance abuse treatment31(4), 319-328.


  1. Tolentino, J. C., & Schmidt, S. L. (2018). DSM-5 Criteria and Depression Severity: Implications for Clinical Practice. Frontiers in psychiatry9, 450. https://doi.org/10.3389/fpsyt.2018.00450

How It Works

For those seeking addiction treatment for themselves or a loved one, our calls are confidential and are available for 24/7 help.

Calls from your area will be answered by Legacy Healing Center, and network of treatment centers who can be found here www.rehabsnearyoudisclosures.com

We are available 24/7 to discuss your treatment options. Our representatives work for a treatment center and will discuss whether their facility may be an option for you.

These calls are offered at no cost to you and with no obligation to enter into treatment. Neither this site nor anyone who answers the call receives a commission or fee dependent upon which treatment provider a visitor may ultimately choose.

If you wish to explore additional treatment options or connect with a specific rehab center, you can: browse top-rated listings, visit our homepage, or visit SAMHSA, at www.samhsa.gov, or by calling 800-662-HELP. You may also contact The Florida Department of Children and Family Services at https://www.myflfamilies.com/